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Accumulation of free fatty acids (FFAs) in hepatocytes causes lipotoxicity mediated by oxidative stress

Efforts were made to minimize the number of animals used and their suffering throughout the study

This happened at much higher non-physiologically relevant concentrations than that stimulated by glucagon previously demonstrated by Samols group (Samols, Marri, Marks, 1966)

The PBN molecule is converted to nitroxides with reactions with radicals

The glymphatic pathway in neurological disorders

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